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William Smith (1756 – 1835) was a leading independent British politician, sitting as Member of Parliament (MP) for more than one constituency. He was an English Dissenter and was instrumental in bringing political rights to that religious minority. He was a friend and close associate of William Wilberforce and a member of the Clapham Sect of social reformers, and was in the forefront of many of their campaigns for social justice, prison reform and philanthropic endeavour, most notably the abolition of slavery. He was the maternal grandfather of pioneer nurse and statistician Florence Nightingale.